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. 2012 Aug 6;7(8):10.1371/annotation/d52a610e-6a56-4158-90bf-45e37f053567. doi: 10.1371/annotation/d52a610e-6a56-4158-90bf-45e37f053567

Correction: Effects of Combined Ketamine/Xylazine Anesthesia on Light Induced Retinal Degeneration in Rats

Blanca Arango-Gonzalez, Andreas Schatz, Sylvia Bolz, Javier Eslava-Schmalbach, Gabriel Willmann, Ahmad Zhour, Eberhart Zrenner, M Dominik Fischer, Florian Gekeler
PMCID: PMC3414543

The following reference was omitted from the article:

Wen R, Cheng T, Li Y, Cao W, Steinberg RH. Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J Neurosci. 1996 Oct 1;16(19):5986-92.

Our findings were supported by the work of Wen et al. who showed a protection of light induced photoreceptor degeneration after multiple injections of xylazine (4 to 7 injections). The protective mechanism by xylazine, an a2-agonist has been traced back to the expression of bFGF. However these findings were shown for a different light damage paradigm (7 days of light exposure) compared to the one used in this present study (single exposure for 2h). Additionally, our study investigated the effect of a single application, rather than multiple injections, of xylazine/ketamine, thus mimicking the widely used paradigm for procedural anesthesia in rodents.

Footnotes

Competing Interests: No competing interests declared.


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