Abstract
Clinically significant methemoglobinemia is rare and difficult to diagnose when other causes of cyanosis are likely. We report a patient in whom unstable angina pectoris and chronic obstructive pulmonary disease were assumed to be responsible for preoperative cyanosis. The use of cardiopulmonary bypass for aortocoronary grafting enabled the clinical diagnosis of methemoglobinemia to be made.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Curry S. Methemoglobinemia. Ann Emerg Med. 1982 Apr;11(4):214–221. doi: 10.1016/s0196-0644(82)80502-7. [DOI] [PubMed] [Google Scholar]
- Fibuch E. E., Cecil W. T., Reed W. A. Methemoglobinemia associated with organic nitrate therapy. Anesth Analg. 1979 Nov-Dec;58(6):521–523. doi: 10.1213/00000539-197911000-00018. [DOI] [PubMed] [Google Scholar]
- Green E. D., Zimmerman R. C., Ghurabi W. H., Colohan D. P. Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia. JACEP. 1979 Oct;8(10):426–431. doi: 10.1016/s0361-1124(79)80409-8. [DOI] [PubMed] [Google Scholar]
- Harvey J. W., Keitt A. S. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Br J Haematol. 1983 May;54(1):29–41. doi: 10.1111/j.1365-2141.1983.tb02064.x. [DOI] [PubMed] [Google Scholar]
- Jaffe E. R., Hsieh H. S. DPNH-methemoglobin reductase deficiency and hereditary methemoglobinemia. Semin Hematol. 1971 Oct;8(4):417–437. [PubMed] [Google Scholar]
- Jeffery W. H., Zelicoff A. P., Hardy W. R. Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine. Drug Intell Clin Pharm. 1982 Feb;16(2):157–159. doi: 10.1177/106002808201600212. [DOI] [PubMed] [Google Scholar]
- Nathan D. M., Siegel A. J., Bunn H. F. Acute methemoglobinemia and hemolytic anemia with phenazopyridine: possible relation to acute renal failure. Arch Intern Med. 1977 Nov;137(11):1636–1638. [PubMed] [Google Scholar]
- Smith R. P., Olson M. V. Drug-induced methemoglobinemia. Semin Hematol. 1973 Jul;10(3):253–268. [PubMed] [Google Scholar]
- Zurick A. M., Wagner R. H., Starr N. J., Lytle B., Estafanous F. G. Intravenous nitroglycerin, methemoglobinemia, and respiratory distress in a postoperative cardiac surgical patient. Anesthesiology. 1984 Oct;61(4):464–466. doi: 10.1097/00000542-198410000-00019. [DOI] [PubMed] [Google Scholar]
