Table 1. Resting Zone to Proliferative Zone.
Bioinformatic analysis of the genes changing from resting zone to proliferative zone in the growth plate cartilage of 1 wk old rats using the computer program Ingenuity Pathway Analysis 7.1.
| Upregulated Genes | No of genes |
|---|---|
| P <0.01 | 677 |
| P <0.01, ≥ 2.0 fold | 153 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Cellular Development | 6.74E-06 | 29 |
| Cellular Growth and Proliferation | 6.74E-06 | 45 |
| Cell Morphology | 1.02E-04 | 14 |
| Cellular Compromise | 3.71E-04 | 13 |
| Cell Cycle | 6.06E-04 | 14 |
| Downregulated Genes | No of genes |
|---|---|
| P <0.01 | 631 |
| P <0.01, ≥ 2.0 fold | 241 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Skeletal and Muscular System Development and Function | 8.68E-09 | 81 |
| Tissue Development | 8.27E-08 | 100 |
| Small Molecule Biochemistry | 2.31E-05 | 43 |
| DNA Replication, Recombination, and Repair | 2.31E-05 | 29 |
| Nucleic Acid Metabolism | 2.31E-05 | 16 |
| Functional Pathways | P value | Ratio* |
|---|---|---|
| VDR/RXR Activation | 1.710E-02 | 8/80 (10.0%) |
| PDGF Signaling | 3.027E-02 | 7/77 (9.1%) |
| BMP Signaling | 3.155E-02 | 7/80 (8.8%) |
| Notch Signaling | 3.184E-02 | 4/41 (9.8%) |
Ratio = number of molecules with P > 0.05/total number of molecules in the pathway