Characteristics of rhegmatogenous retinal detachment in pseudophakic and phakic eyes

Abstract

Aims

To investigate whether pseudophakic and phakic rhegmatogenous retinal detachment (RRD) patterns differ.

Methods

Retrospective review of electronic database of patients, aged 50 years or over, presenting to our vitreoretinal service. Data included baseline characteristics, digital drawings, and outcomes. Retinal drawings were analysed in a masked fashion for site, size, and number of retinal breaks. Comparisons were made between the following groups and subgroups: pseudophakic eyes, phakic eyes, phakic eyes with cataract, and phakic eyes without cataract.

Results

Of 500 eyes included, 146 were pseudophakic; 177 of the phakic eyes had cataract. The following were significant by univariate analysis: pseudophakic patients were older than phakic patients in general, but the same age as patients with cataract; in the pseudophakic group, there were lower proportions of females and of patients presenting with vitreous haemorrhage or with large or superotemporal breaks; higher proportions of pseudophakic eyes had small breaks and inferonasal breaks. Some differences remained significant when comparing pseudophakia eyes with cataract. Multivariate analysis comparing pseudophakia with phakia confirmed a lower chance in pseudophakia of large breaks, vitreous haemorrhage and superotemporal breaks, but higher chance of detached inferior breaks. Some variables were age dependent.

Conclusion

Differences were found between pseudophakic and phakic RRD patterns. These suggest special pathogenetic mechanisms in pseudophakic retinal detachment, which could help explain increased incidences of RRD after cataract surgery.

Introduction

Cataract surgery has evolved rapidly in the last 40 years, progressing from intracapsular surgery and postoperative aphakia to extracapsular surgery with implantation of anterior chamber intraocular lenses, to phacoemulsification with continuous curvilinear capsulorhexis and insertion of posterior chamber lenses. This has led to a reduction in complications and improved postoperative outcome. The relationship between cataract surgery and rhegmatogenous retinal detachment (RRD) has been studied using data from Medicare and other insurance information,^{1, 2, 3} Scandinavian public health data,^{4, 5} and large population-based studies such as The Rochester Study.^{6, 7} These studies suggest an increased risk of retinal detachment associated with cataract operations despite progress in surgical technique. The 4-year incidence of retinal detachment after all cataract extractions has been reported as 1.17%, with higher rates in cases of vitreous loss (4.9%) and a lower rate with the use of phacoemulsification (0.4%).⁸ This is higher than would be expected in the normal population: studies have reported an annual incidence of retinal detachment of between 6.3 and 17.9 per 100 000.⁹ Epidemiological data, however, do not discriminate between an association of cataract with retinal detachment or cataract surgery with retinal detachment. It is possible that the presence of a cataract itself is a marker for higher risk of retinal detachment. It has been shown, for example, that patients with a retinal detachment in a pseudophakic eye have a significant risk of an RRD in the other eye even if that eye does not undergo cataract surgery.¹⁰

A potential strategy for exploring the link between retinal detachment and cataract surgery is to examine the clinical pattern of retinal detachment, for example, position, size, and type of retinal breaks, and to see if this differs between pseudophakic and phakic eyes. If differences in pattern are observed, this may suggest a difference in the pathogenetic mechanism. Previous studies have been performed in this regard in the 1960s and 1970s when intracapsular cataract surgery and aphakia were common.^{11, 12, 13, 14, 15} However, to our knowledge, there are no studies in the English language literature on the pattern of retinal detachment in the era of phacoemulsification, an operation regarded as less traumatic to the internal structures of the eye than both intracapsular and extracapsular surgery, and leading to pseudophakia, usually with an intact capsular bag, rather than aphakia.

Materials and methods

Data from all patients attending a single author's (THW) vitreoretinal surgery service were prospectively entered into an electronic patient record (Microsoft Access, available with the book Vitreoretinal Surgery¹⁶). The electronic patient record requires recording of retinal detachment characteristics and digital drawings of the retinal detachment. The duration of symptoms, type of breaks, number of breaks, presence of proliferative vitreoretinopathy (PVR) according to the revised Retinal Society classification,¹⁷ extent of retinal detachment, foveal status, presence of vitreous haemorrhage, and visual acuity (determined using Snellen charts, but converted to logMAR) were recorded. In addition, preoperative data on the status of the lens (including presence of visually significant cataract or pseudophakia) and date of prior cataract surgery were recorded. Ethical approval for the database study was obtained from the local research ethics committee (Guys and St Thomas' Hospitals Trust).

For patients who developed retinal detachment in both eyes, only the first eye was included in the present study. Patients under 50 years of age, or with aphakia, anterior chamber lens implant, giant retinal tear, retinal dialysis, macular hole related RRD, retinoschisis-related RRD, and dislocated lens nucleus during cataract surgery were excluded.

Retinal drawings were reviewed by an observer (THW) who was masked to the clinical data of the patient. Drawings were divided into four quadrants centred at the fovea: superotemporal, superonasal, inferotemporal, and inferonasal. The observer recorded whether the eye had any breaks (true or false) in any of the four quadrants. This method was used to avoid any conflict of dependant variables that would arise by counting the numbers of breaks in each quadrant and using these as independent variables, a procedure that has been used in prior studies,^{18, 19} resulting in erroneous statistical analysis, as multiple breaks in the same eye are not independent variables. The presence of inferior breaks was recorded, specifically noting whether breaks were present between 5 and 7 o'clock (true or false), or at 4–5 or 7–8 o'clock (true or false), and whether these were in flat or detached retina. Such breaks can present particular challenges in surgical management, compared with breaks elsewhere, hence this subdivision was not applied to superior, nasal, or temporal breaks. Eyes were regarded as having an anterior break if a break was identified anterior to a line halfway between the equator and the ora serrata. Eyes had a posterior break if a break was seen posterior to a line of similar distance posteriorly from the equator as the ora serrata was anterior to the equator.

In addition, breaks were regarded as small, medium, and large according to their longest meridian and related to the optic disc diameter. A small break was defined as <0.5 disc diameter; medium break size was 0.5–2 disc diameters; and large >2 disc diameters. Eyes were recorded (true or false) as having small, medium, or large breaks. Thus, a single eye could have small, medium, and large breaks if all sizes were present.

Data were analysed using statistical software for univariate analysis (Analyse-it, Cambridge, UK) and multivariate logistic regression analysis (using the R statistical language). Pair-wise comparisons for each variable were made between pseudophakic eyes (‘pseudophakia') and phakic eyes (‘phakia'), between pseudophakic eyes and phakic eyes with cataract (‘phakic cataract'), and between phakic eyes without cataract (‘phakic non-cataract') and phakic eyes with cataract (‘phakic cataract'). Means were compared using t-test and proportions using Fisher's exact test.

Results

A total of 535 eyes from 535 patients were included in the study. Thirty-five drawings were missing or inadequate, so these eyes were excluded from analysis. Of the 500 patients, 354 were phakic, of whom 177 had visually significant cataract, and 146 were pseudophakic. The duration since cataract surgery was known for 130 of the 146 pseudophakic eyes, and ranged from 3 days to 20 years (median 1.94 years)—see Figure 1. There was a history of YAG capsulotomy in 14.0% of the pseudophakic eyes and a history of cataract surgery complicated by posterior capsular tear in 10.5%. However, these numbers may represent under-estimates as the complete records of previous ocular history were not always available, particularly as referrals were primarily from other hospitals to the tertiary vitreoretinal service.

Figure 1.

Histogram of the duration between cataract surgery and operation for retinal detachment in years for the 130 pseudophakic eyes for which this was known.

The following data were for the group as a whole: median duration of vision loss was 8 days; median follow-up was 10 months; the right eye was involved in 53% the fovea was off at presentation in 58% the mean number of breaks was 2.5; multiple breaks (more than one break) were present in 55% and no hole was found in 1%. The rate of PVR at presentation of grades B or C was 14%. Surgical success rates were similar between the groups with primary success rate of 85% and secondary success rate of 96%.

Univariate analysis

Table 1 shows the results of univariate comparisons between the different groups. The following differences were significant: pseudophakic patients were older than phakic patients in general, but the same age as phakic patients with cataract; in the pseudophakic group, there was a lower proportion of females, a lower proportion presenting with vitreous haemorrhage, and a lower proportion with large breaks or superotemporal breaks; however, a higher proportion of pseudophakic eyes had small breaks and inferonasal breaks compared with the other groups. See Figure 2 (upper panel) for comparison of proportions with large or small breaks and superotemporal or inferonasal breaks in pseudophakia and phakia. Several of these differences were seen also when comparing pseudophakic eyes specifically with phakic eyes with cataract (Table 1), but statistical significance was not reached in all cases. This may be expected as numbers are smaller for this subgroup comparison, although a trend is still discernible.

Table 1. Features of retinal detachments in pseudophakic and phakic eyes.

Variable	Pseudophakic eyes (n=146)	All phakic eyes (n=354)	Phakic eyes with cataract (n=177)	Phakic eyes without cataract (n=177)	P-value (pseudophakic vs phakic)	P-value (pseudophakic vs phakic cataract)	P-value (phakic cataract vs phakic without cataract)
Baseline characteristics
Age in years (mean±𝒮𝒟	68.9±9.9	64.2±9.2	68.3±9.9	60.2±6.3	<0.0001*	0.570	<0.0001*
Sex (% female)	31.5	41.5	42.9	40.1	0.045*	0.046*	0.666
Presenting features
Presenting logMAR acuity (mean±𝒮𝒟	0.96±0.74	0.90±0.77	1.11±0.75	0.68±0.74	0.404	0.073	<0.0001*
Duration of visual loss in days (mean±𝒮𝒟	15.5±23.6 (n=116)	31.4±94.5 (n=276)	34.2±80.8 (n=140)	28.5±107 (n=136)	0.074	0.017*	0.619
Vitreous haemorrhage at presentation? (%)	6.8	17.2	16.4	18.1	0.002*	0.013*	0.779
Presence of PVR (%)	14.4	13.6	19.8	7.3	0.909	0.260	0.001*
Number of breaks (mean±𝒮𝒟	2.5±2.3	2.7±2.5	2.7±2.6	2.6±2.3	0.638	0.607	0.812
Fovea off? (%)	63.7	55.4	67.2	56.5	0.105	0.583	<0.0001*
Presence of different sized breaks
Small breaks present? (%)	56.2	46.0	46.3	45.8	0.050*	0.099	1.00
Medium breaks present? (%)	60.3	59.0	52.0	66.1	0.879	0.167	0.009*
Large breaks present? (%)	13.0	27.1	31.6	22.6	0.0007*	0.0001*	0.073
Break position by quadrant
Superotemporal break? (%)	64.4	74.9	74.6	75.1	0.025*	0.062	1.00
Inferotemporal break? (%)	26.7	31.9	32.8	31.1	0.296	0.289	0.820
Superonasal break? (%)	38.4	38.4	40.1	36.7	1.00	0.836	0.585
Inferonasal break? (%)	21.2	13.6	13.6	13.6	0.049*	0.094	1.00
Anterior or posterior break position
Anterior break? (%)	28.1	21.2	19.2	23.2	0.125	0.081	0.435
Posterior break? (%)	13.0	16.7	16.9	16.4	0.376	0.410	1.00
Position of inferior flat breaks
Flat break 4–5 or 7–8 o'clock? (%)	1.4	4.8	3.4	6.2	0.101	0.427	0.320
Flat break 5–7 o'clock? (%)	8.2	8.5	8.5	8.5	1.00	1.00	1.00
Position of inferior breaks involved in RD
Break in RD 4–5 or 7–8 o'clock? (%)	9.6	8.5	7.9	9.0	0.807	0.735	0.849
Break in RD 5–7 o'clock? (%)	13.0	7.3	7.9	6.8	0.071	0.186	0.839
Outcome measures
Years of follow-up (mean±𝒮𝒟	0.72±1.10	0.92±1.09	0.98±1.19	0.85±0.98	0.071	0.045*	0.267
logMAR acuity at last follow-up (mean±𝒮𝒟	0.46±0.56	0.44±0.52	0.50±0.55	0.39±0.48	0.822	0.487	0.046*
Any RD at final follow-up? (%)	4.8	4.0	5.1	2.8	0.833	1.00	0.414
Oil in at final follow-up? (%)	9.6	5.4	7.3	3.4	0.132	0.599	0.156
Phthisis at final follow-up? (%)	1.4	0.0	0.0	0.0	0.170	0.407	1.00

Asterisk denotes significance at the 5% level. Total numbers of eyes given in the top row apply to all rows except for ‘duration of visual loss' where numbers are smaller (displayed in each cell) due to missing data for some eyes.

Figure 2.

Comparison of proportions of patients (%) with large, small, superotemporal, or inferonasal breaks in pseudophakic vs phakic eyes (upper panel) and in pseudophakic vs phakic eyes with cataract (lower panel). P-values found by univariate analysis.

The lower panel of Figure 2 compares the same variables as in the upper panel, but between the pseudophakic and phakic cataract groups. Here, the same trend is observed: pseudophakic eyes have a lower proportion with large or superotemporal breaks and higher proportions with small or inferonasal breaks, but the numbers fail to reach statistical significance for three out of the four comparisons.

Most variables were similar in phakic cataract and phakic non-cataract groups, except for the following where statistically significant differences were observed (see Table 1): phakic non-cataract patients were younger (as mentioned earlier) and had better presenting and final acuity; a lower proportion presented with the fovea detached or with PVR; and a higher proportion had medium-sized breaks compared with the phakic cataract group.

Multivariate analysis

Multivariate analysis confirmed a lower chance of large breaks in pseudophakia compared with phakia. Vitreous haemorrhage and superotemporal breaks were less common in pseudophakia. Detached inferior breaks between 5 and 7 o'clock hours were more common in pseudophakia. Pseudophakic patients were more likely to have RRD involving four quadrants. See Table 2 for odds ratios (ORs). After multivariate analysis, differences for small breaks were not significant.

Table 2. Multivariate analysis comparing pseudophakia with phakia.

	Odds ratio (95% confidence interval)
Large breaks	0.43 (0.25, 0.73)
Small breaks	Not significant
Vitreous haemorrhage	0.35 (0.18, 0.71)
Superotemporal breaks	0.63 (0.41, 0.96)
Inferior break 5–7 o'clock in RRD	1.9 (1.01, 3.53)
Four quadrant RRD	8.68 (1.15, 68.3)

Abbreviation: RRD, rhegmatogenous retinal detachment.

Mulitivariate comparison between pseudophakic eyes and phakic eyes with cataract confirmed that there was a higher chance of large breaks in the phakic cataract group (OR 2.36, 95% confidence interval (CI): 1.51, 3.69).

Multivariate comparison between the two phakic groups (phakic cataract and phakic non-cataract) showed that, if cataract were present, there was a higher chance of fovea off (OR 2.60, 95% CI: 1.69, 4.00) and a lower chance of medium breaks (OR 0.59, 95% CI: 0.39, 0.90) or retinal detachment in only 1, 2, or 3 quadrants (OR 0.46, 95% CI: 0.26, 0.82). No other comparisons (including presence of large breaks) were significant by multivariate analysis between the two phakic groups.

Two variables were age dependent: the presence of inferonasal breaks and presence of foveal detachment at presentation. Figure 3 shows how the OR changes with age group (together with CIs): inferonasal breaks were significantly more likely in pseudophakia overall, but the OR increased with age; foveal detachment was also more likely in pseudophakia, but here the OR declined with age. None of the other variables showed such age dependence.

Figure 3.

Odds ratio for the presence of inferonasal break (left panel) or foveal detachment (right panel) in pseudophakia compared with phakia, as a function of age (in years), found by multivariate analysis. Dotted lines plot 95% confidence intervals.

Discussion

This study aimed to explore differences in retinal detachment patterns in pseudophakia compared with phakia. Several differences were statistically significant, and a similar trend was discernible even when comparing pseudophakic patients specifically with phakic patients with cataract, but statistical significance was not achieved as frequently. Some of the differences were also observed by multivariate analysis.

A higher proportion of males was found in all groups, agreeing with epidemiological studies that have shown a greater incidence of retinal detachment in males.²⁰ The male predilection for RRD was more pronounced in pseudophakic RRD despite the higher number of cataract operations performed on female patients in the general population and most studies showing more presentations of symptomatic posterior vitreous detachments in females.^{21, 22, 23} This difference between the sexes remains unexplained at present.

Age can affect the pattern of retinal detachment,²⁴ so steps were taken to control this. Patients under 50 years of age were excluded so that the pseudophakic and phakic groups would be comparable, and indeed the pseudophakic and phakic cataract groups had the same mean age. Also, multivariate analysis was used to control for age dependence: the ORs for only two variables were found to show age dependence (Figure 3).

Patients who were pseudophakic were less likely to have vitreous haemorrhage as a presenting feature, and this may be related to the smaller number of eyes with large breaks seen in this group. The most common site for breaks was superotemporal in all groups but this area was less often involved in pseudophakia than in phakia. Inferonasal breaks were more common in pseudophakia by univariate analysis, and there was a greater chance of detached breaks inferiorly between 5 and 7 o'clock in pseudophakia after multivariate analysis.

Many variables were similar between phakic patients with cataract and phakic patients without cataract, although a lower proportion of eyes with medium-sized breaks, a greater proportion with PVR and a greater proportion with detached foveas were observed in patients with cataract by univariate analysis. Multivariate analysis confirmed that the presence of cataract in a phakic eye gave a lower chance of medium-sized breaks and a higher chance of detached fovea. The biological basis for this is unclear. Phakic eyes with cataract were more likely to have large, and less likely to have medium, breaks than those without cataract, whereas the proportions of small breaks were similar in both groups (Table 1), and so one would postulate that eyes with larger breaks would be likely to have progressed to foveal detachment by presentation.

In our study, ∼10.5% of pseudophakic patients had undergone cataract extraction complicated by posterior capsular tear, and 14% had undergone a YAG capsulotomy. Such events could be important in the development of the pseudophakic RRD pattern that we observe. However, subgroup analysis of these data within our study would be unlikely to yield reliable conclusions given that the numbers are small and there was uncertainty over the actual proportions of eyes that had undergone YAG capsulotomy or complicated cataract extraction, because of lack of availability of full records of prior ocular history in many cases. By excluding patients with anterior chamber lens implants, aphakia, and dislocated nuclear lens fragments, we hoped to reduce the influence of severely complicated cataract operations on the results.

Koo et al²⁵ compared retinal detachments in 206 phakic and 37 pseudophakic eyes. The male preponderance was similarly more marked in the pseudophakic group. High myopia and peripheral retinal degenerations were more common in the phakic group. The proportion with two or more breaks was greater in the phakic group. The proportion with detachment involving three or four quadrants, or involving the macula, was greater in the pseudophakic group, similar to the findings of our study. However, their study differed from ours as it included all age groups, and had a relatively small pseudophakic group (37 eyes), of which significant proportions had posterior capsular rupture (40.5%) and no break found (27%). The presence of high myopia was not recorded in our study, and may have relevance in affecting the pattern of detachment.

Interestingly, previous studies of aphakic retinal detachment show a pattern of difference between aphakic and phakic retinal detachment, which bears some similarities to the present study. Phillips¹⁸ in 1963 found that a greater proportion of aphakic retinal detachments had inferior breaks and more peripheral breaks compared with phakic eyes. Norton²⁶ reported in 1964 that compared with phakic eyes, aphakic eyes were less likely to have superotemporal breaks, or to present with the macula attached or vitreous haemorrhage. Everett and Katzin²⁷ in 1968 found that aphakic eyes had a lower percentage of females, a lower proportion with superotemporal breaks, and a higher proportion with inferonasal breaks compared with phakic eyes, and these findings were also seen in the large series of Ashrafzadeh et al.¹⁹ The latter study found that more aphakic eyes had oral and fewer had equatorial breaks than the phakic group. Aphakic eyes were in addition more likely to have total retinal and macular detachment, and were slightly less likely to present with vitreous haemorrhage, although the difference here was not statistically significant.

The older studies used a system of counting the number of breaks in each quadrant, providing a total number of breaks in each quadrant over a cohort. Applying statistical analysis using this methodology is more complicated because breaks from the same eye are not independent variables. The use of this method may explain the increased percentages described in these studies compared with the present study in which the eye was only classified as having breaks present or absent in each quadrant or area of the retina, regardless of the number.

Yoshida et al²⁸ compared retinal detachment characteristics in aphakic and pseudophakic eyes (following intracapsular or extracapsular extraction) in 1992. They found that the aphakic group tended to have smaller and more peripheral breaks, leading the authors to speculate that pseudophakic retinal detachments may be more similar to those seen in phakic eyes than aphakic eyes. However, they found no significant difference in the quadrantal location of retinal breaks between the groups.

Previous population-based studies suggest a reduction in the incidence of pseudophakic retinal detachment with phacoemulsification compared with intracapsular cataract extraction.⁸ Our study has shown a pattern of pseudophakic RRD, after phacoemulsification, which has some striking similarities to the aphakic retinal detachments seen in the 1960s and 70s. It is possible that there is a disproportionate effect of some patients undergoing YAG capsulotomy or complicated cataract extraction on the position of retinal breaks. However, it is quite plausible that the physical effect of replacing a large cataractous lens with a small plastic intraocular lens causes changes in vitreous anatomy that influences the type and position of retinal break. It has been postulated that cataract surgery is more likely to induce an anomalous posterior vitreous detachment (relevant studies reviewed by Coppe and Lapucci²⁹), thus conferring an increased risk of RRD. We suggest that this may also account for the differences in pattern of RRD shown in our study. The greater proportions of inferonasal breaks seen in pseudophakic eyes in our study, or aphakic eyes in previous studies, is interesting. Cataract surgery incisions are usually superior or temporal, but whether or how this might contribute to vitreous dynamics and patterns of retinal break is unknown.

Some potential limitations of the present study deserve mention. Although all retinal drawings were analysed consistently by a single author, the drawings themselves were made by different surgeons, who may have estimated break size differently. Visualisation of breaks may also differ among patient groups: the presence of an intraocular lens may make breaks appear smaller or affect their perceived position; breaks may also be more difficult to detect in the pseudophakic eye because of obscuration by the lens edge or by capsular opacification. However, the presence of cataract, or vitreous haemorrhage (which was more common in phakic eyes), may have a similar effect. The presence or absence of lattice degeneration, which could have a bearing on the pattern of retinal break or detachment, was also not recorded.

A further limitation concerns division of the phakic group into those with or without visually significant cataract. Given that a spectrum of lens opacity exists, such distinction may be somewhat subjective and arbitrary. The study has partly assumed that the only difference between the phakic cataract group and the pseudophakic group is the event of the cataract operation. It is quite possible that there are other differences between these eyes that explain why some had undergone cataract extraction and others had not, and it may be that these underlying differences could explain the different RRD patterns.

In summary, patients with pseudophakic retinal detachment appear to have a pattern of retinal detachment which differs from that seen in phakic patients and also from that seen in phakic patients with cataract. This suggests that the event of phacoemulsification cataract surgery itself may contribute to a distinct pathogenetic mechanism for retinal detachment in these patients. Although patterns are broadly similar between the groups, the presence of statistically significant differences and of similar trends observed in both comparisons (pseudophakia vs phakia and pseudophakia vs phakic cataract), together with the similarities to historical descriptions of aphakic retinal detachment after intracapsular cataract surgery, suggest that cataract surgery itself could be a determining factor.

The authors declare no conflict of interest.