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. 1978 Mar;5(3):691–696. doi: 10.1093/nar/5.3.691

Template specific inhibitors of E. coli RNA polymerase.

H J Chou, J P Froehlich, J Pitha
PMCID: PMC342016  PMID: 347401

Abstract

Electroneutral analogs of polynucleotides, poly-9-vinyladenine and poly-1-vinyluracil inhibit E. coli RNA polymerase in all combinations where the single stranded polynucleotides are used as templates and the vinyl analogs are complementary to them. As templates both the ribo- and deoxyribopolynucleotides were tested; variation of the template concentration in the presence of vinyl analogs produced a competitive pattern of inhibition. The electroneutral analogs do not inhibit the enzyme activity when non-complementary single stranded polynucleotides or double stranded polynucleotides are used as templates; the latter fully supports transcription even when one of the strands is complementary to the analog.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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