Abstract
Polyamines and other charged amines bind to RNA by hydrogen bonding to the 3' phosphate and to the 2' OH. This mode of binding suggests a mechanism by which DNA and RNA might be distinguished by enzymes.
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Selected References
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- Flink I., Pettijohn D. E. Polyamines stabilise DNA folds. Nature. 1975 Jan 3;253(5486):62–63. doi: 10.1038/253062a0. [DOI] [PubMed] [Google Scholar]
- Gabbay E. J., Adawadkar P. D., Wilson W. D. Stereospecific binding of diastereomeric peptides to salmon sperm DNA. Biochemistry. 1976 Jan 13;15(1):146–151. doi: 10.1021/bi00646a022. [DOI] [PubMed] [Google Scholar]
- Gosule L. C., Schellman J. A. Compact form of DNA induced by spermidine. Nature. 1976 Jan 29;259(5541):333–335. doi: 10.1038/259333a0. [DOI] [PubMed] [Google Scholar]
- Maestre M. F., Tinoco I., Jr Optical rotatory dispersion of viruses. J Mol Biol. 1967 Feb 14;23(3):323–335. doi: 10.1016/s0022-2836(67)80108-6. [DOI] [PubMed] [Google Scholar]
- Rich A., RajBhandary U. L. Transfer RNA: molecular structure, sequence, and properties. Annu Rev Biochem. 1976;45:805–860. doi: 10.1146/annurev.bi.45.070176.004105. [DOI] [PubMed] [Google Scholar]
- Sakai T. T., Cohen S. S. Effects of polyamines on the structure and reactivity of tRNA. Prog Nucleic Acid Res Mol Biol. 1976;17:15–42. doi: 10.1016/s0079-6603(08)60064-1. [DOI] [PubMed] [Google Scholar]
- Tabor H., Tabor C. W. Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. Adv Enzymol Relat Areas Mol Biol. 1972;36:203–268. doi: 10.1002/9780470122815.ch7. [DOI] [PubMed] [Google Scholar]
- Thrierr J. C., Deubel V., Leng M. Interaction between polyribouridylic acid and spermine. Biochimie. 1972;54(9):1115–1119. doi: 10.1016/s0300-9084(72)80015-4. [DOI] [PubMed] [Google Scholar]