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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Hypertension. 2012 Jul 9;60(3):697–704. doi: 10.1161/HYPERTENSIONAHA.112.198242

Figure 2. Hypoxia increases CpG methylation at ERα promoter.

Figure 2

CpG methylation of USF-15, Sp1-520 and PRA/B-563 binding sites at ERα promoter region was determined in uterine arteries isolated from nonpregnant and pregnant sheep maintained at sea level (normoxic control, C) or exposed to high-altitude hypoxia (H) for 110 days (A), and in uterine arteries of normoxic animals treated ex vivo with 21.0% O2 (normoxic control, C) or 10.5% O2 (H) for 48 hours (B). Data are means ± SEM. * P < 0.05, versus nonpregnant; + P < 0.05, versus normoxic control. n = 5–10