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. 1978 Jun;5(6):1907–1917. doi: 10.1093/nar/5.6.1907

Transcription of DNA-histone complexes by yeast RNA polymerase B.

L K Karagyozov, M A Valkanov, A A Hadjiolov
PMCID: PMC342133  PMID: 353733

Abstract

Transcription of denatured DNA complexed with histones (total, H1 or H2A/H2B/H3/H4) by yeast RNA polymerase B is investigated. Binding of histones to DNA restricts its template activity by decreasing the formation of active, heparin-resistant, RNA polymerase initiation complexes. The elongation of pre-initiated RNA on denatured DNA, complexed with histones, is possible, although resulting in somewhat shorter RNA chains. It is suggested that RNA polymerase B can elongate on a DNA strand covered with histones.

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1907

Selected References

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