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. 1978 Jun;5(6):1955–1970. doi: 10.1093/nar/5.6.1955

Base pairing structure in the poly d(G-T) double helix: wobble base pairs.

T A Early, J Olmsted 3rd, D R Kearns, A G Lezius
PMCID: PMC342137  PMID: 673842

Abstract

High resolution nuclear magnetic resonance (NMR) and ethidium bromide binding studies are used to demonstrate that poly d(G-T) forms an ordered double helical structure at low temperatures (below 24 degrees C in 0.3 M NaCl) in which G and T are hydrogen bonded together in a wobble base pair hydrogen bonding scheme as proposed earlier by Lezius and Domin. Alternative hydrogen bonding schemes involving the tautomeric form of either T or G, such as have been proposed to account for mutation rates in DNA synthesis, are eliminated.

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1955

Selected References

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