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. 1978 Sep;5(9):3141–3156. doi: 10.1093/nar/5.9.3141

Nucleotide sequence of the O gene and of the origin of replication in bacteriophage lambda DNA.

G Scherer
PMCID: PMC342237  PMID: 704348

Abstract

The nucleotide sequence of the O gene in bacteriophage lambda DNA is presented. According to two possible initiator codons, the primary structure of the O protein deduced from the DNA sequence consists of 278 or 299 amino acid residues. Structure and function of the O protein--one of the two phage initiator proteins for lambda DNA replication--are discussed in the light of a secondary structure model for the O protein. The central part of the O gene contains a cluster of symmetrical sequences extending over 160 base pairs. The point mutation of the cis-dominant replication mutant ti12 is located in this region.

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Selected References

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