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. 1979 Dec 20;7(8):2431–2438. doi: 10.1093/nar/7.8.2431

The preferential codon usages in variable and constant regions of immunoglobulin genes are quite distinct from each other.

T Miyata, H Hayashida, T Yasunaga, M Hasegawa
PMCID: PMC342394  PMID: 523321

Abstract

The pattern of codon utilization in the variable and constant regions of immunoglobulin genes are compared. It is shown that, in these regions, codon utilizations are quite distinct from one another: For most degenerate codons, there is a selective bias that prefers C and/or G ending codons to U and/or A ending codons in the constant region compared with the bias in the variable region. This would strongly suggest that, in immunoglobulin genes, the bias in code word usage is determined by other factors than those concerning with the translational mechanism such as tRNA availability and codon-anticodon interaction. A possibility is also suggested that this differance of code word usage between them is due to the existence of secondary structure in the constant region but not in the variable region.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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