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. 1977 Jan;4(1):141–148. doi: 10.1093/nar/4.1.141

Levels of DNA polymerase-alpha and beta in normal and xeroderma pigmentosum fibroblasts.

U Bertazzoni, M Stefanini, G Pedrali-Noy, F Nuzzo, A Falaschi
PMCID: PMC342415  PMID: 866172

Abstract

We have determined the levels of DNA-polymerases-alpha and-beta in fibroblasts obtained from normal subjects and from patients with Xeroderma Pigmentosum (XP) belonging to three different complementation groups and to the variant form. The assays have been performed in crude extracts and after fractionation on sucrose gradients. The levels of alpha and beta-polymerases in the different cases of XP were found to lie within the same range as the control values, and no correlation was found with the severity of the symptoms. The sedimentation coefficients of the two polymerases from all the pathological lines were identical to those of the normal fibroblasts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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