Abstract
The secondary structure of methyl ester of deoxyadenylyl- - (5' - 3') - deoxyadenylyl - (5' leads to N) - L-phenylalanine / L- PheOMe - d(pApA)/ was investigated using proton magnetic resonance. The folded conformation stabilized by hydrophobic interactions in aqueous solution was shown for this compound. The investigation of the chemical shifts of aromatic protons of L- PheoOMe - d(pApA) permitted us to construct the conformational model of this compound.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arnone A., Bier C. J., Cotton F. A., Day V. W., Hazen E. E., Jr, Richardson D. C., Yonath A., Richardson J. S. A high resolution structure of an inhibitor complex of the extracellular nuclease of Staphylococcus aureus. I. Experimental procedures and chain tracing. J Biol Chem. 1971 Apr 10;246(7):2302–2316. [PubMed] [Google Scholar]
- Chan S. I., Nelson J. H. Proton magnetic resonance studies of ribose dinucleoside monophoshates in aqueous solution. I. The nature of the base-stacking interaction in adenylyl 3'--5')adenosine. J Am Chem Soc. 1969 Jan 1;91(1):168–183. doi: 10.1021/ja01029a033. [DOI] [PubMed] [Google Scholar]
- Cuatrecasas P., Edelhoch H., Anfinsen C. B. Fluorescence studies of the interaction of nucleotides with the active site of the nuclease of Staphylococcus aureus. Proc Natl Acad Sci U S A. 1967 Nov;58(5):2043–2050. doi: 10.1073/pnas.58.5.2043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giessner-Prettre C., Pullman B. Intermolecular nuclear shielding values for protons of purines and flavins. J Theor Biol. 1970 Apr;27(1):87–95. doi: 10.1016/0022-5193(70)90130-x. [DOI] [PubMed] [Google Scholar]
- Glassman T. A., Cooper C., Harrison L. W., Swift T. J. A proton magnetic resonance study of metal ion-adenine ring interactions in metal ion complexes with adenosine triphosphate. Biochemistry. 1971 Mar 2;10(5):843–851. doi: 10.1021/bi00781a018. [DOI] [PubMed] [Google Scholar]
- Gromova E. S., Tyaglov B. V., Shabarova Z. A. Optical rotatory dispersion and circular dichroism of mono- and oligonucleotide-amino acids (amidates). Biochim Biophys Acta. 1971 Jun 17;240(1):1–11. doi: 10.1016/0005-2787(71)90506-5. [DOI] [PubMed] [Google Scholar]
- Kondo N. S., Fang K. N., Miller P. S., Ts'o P. O. Influence of the furanose on the conformation of adenine dinucleoside monophosphates in solution. Biochemistry. 1972 May 23;11(11):1991–2003. doi: 10.1021/bi00761a001. [DOI] [PubMed] [Google Scholar]
- Meadows D. H., Roberts G. C., Jardetzky O. Nuclear magnetic resonance studies of the structure and binding sites of enzymes. 8. Inhibitor binding to ribonuclease. J Mol Biol. 1969 Nov 14;45(3):491–511. doi: 10.1016/0022-2836(69)90308-8. [DOI] [PubMed] [Google Scholar]
- Miller P. S., Fang K. N., Kondo N. S., Ts'o P. O. Syntheses and properties of adenine and thymine nucleoside alkyl phosphotriesters, the neutral analogs of dinucleoside monophosphates. J Am Chem Soc. 1971 Dec;93(24):6657–6665. doi: 10.1021/ja00753a054. [DOI] [PubMed] [Google Scholar]
- Sternlicht H., Jones D. E., Kustin K. Metal ion binding to adenosine triphosphate. 3. A kinetic analysis. J Am Chem Soc. 1968 Dec 4;90(25):7110–7118. doi: 10.1021/ja01027a041. [DOI] [PubMed] [Google Scholar]
- Tiaglov B. V., Gromova E. S., Zenin S. V., Sergeev G. B., Shabarova Z. A., Prokof'ev M. A. Issledovanie vtorichnoi struktury nukleotidil-(5' leads to N)-aminokislot s razlichnoi prirodoi osnovaniia i aminokisloty. Mol Biol (Mosk) 1975 Sep-Oct;9(5):652–666. [PubMed] [Google Scholar]