Table 1. Demographics, mutation status and DNA methylation levels of the study population, New York site of the BCFR.
| Affected Sisters |
Unaffected Sisters |
|||
|---|---|---|---|---|
| n = 273 | n = 335 | |||
| |
N |
Mean (SD) or % |
N |
Mean (SD) or % |
|
Age |
|
|
|
|
| Continuous |
273 |
49.6 (11.4) |
335 |
48.2 (11.2) |
| Race‡ |
|
|
|
|
| White |
169 |
62.6% |
189 |
56.4% |
| Hispanic |
67 |
24.8% |
102 |
30.4% |
| Other |
34 |
12.6% |
44 |
13.1% |
| Smoking status |
|
|
|
|
| Current |
15 |
5.5% |
41 |
12.2% |
| Former |
96 |
35.2% |
101 |
30.1% |
| Never |
162 |
59.3% |
193 |
57.6% |
|
BRCA1 Mutation |
|
|
|
|
| Positive |
22 |
8.1% |
13 |
3.9% |
| Negative |
251 |
91.9% |
322 |
96.1% |
|
BRCA2 Mutation |
|
|
|
|
| Positive |
12 |
4.4% |
9 |
2.7% |
| Negative |
261 |
95.6% |
326 |
97.3% |
| [3H]-methyl acceptance assay (DPM/μg) |
|
|
|
|
| Continuous |
233 |
97111 (76348) |
295 |
88030 (70841) |
| LUMA (% DNA meth) |
|
|
|
|
| Continuous | 263 | 67.1 (7.6) | 321 | 67.5 (7.3) |
‡
Race information was not available for three unaffected subjects