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. 1978 Nov;5(11):4399–4416. doi: 10.1093/nar/5.11.4399

Spatial configuration of deoxyribotrinucleoside diphosphates in aqueous solution.

D M Cheng, M M Dhingra, R H Sarma
PMCID: PMC342757  PMID: 724520

Abstract

The detailed conformational features and dynamics of the naturally occurring deoxyribotrinucleoside diphosphates d-TpTpT and d-TpTpC have been investigated at 20 degrees C and 80 degrees C in aqueous solution by nuclear magnetic resonance spectroscopy. The observed NMR parameters indicate that the conformational properties of the trimers are very similar to those of the constituent dimers and monomers, i.e., the monomers and dimers conserve their intrinsic conformational features when they become incorporated into oligomers. Model building indicate that the distant shieldings can originate from spatial configurations in which the central nucleotidyl unit is bulged out and the w'1w1, w'2w2 occupy /g+g+, g+g+/ domains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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