Table 1.

Renal and plasma data. Hsd11b2^+/+ and Hsd11b2^+/− mice were maintained on a low sodium (LS; n=7/8), standard sodium (SS; n=8/8) or high sodium (HS; n=11/9) diet. Data are means ± SEM. Statistical comparisons were made using ANOVA with Bonferroni post hoc test. **P<0.01; ^aP<0.001 versus wild-type.

	Parameter	Hsd11b2+/+ LS	Hsd11b2+/− LS	Hsd11b2+/+ SS	Hsd11b2+/− SS	Hsd11b2+/+ HS	Hsd11b2+/− HS
FF*	(%)	30.0 ± 6.1	22.2 ±3.8	23.8 ± 1.7	25.7 ± 1.8	16.8 ± 0.8	42.1 ± 4.1**
RVR†	(mmHg/ml.min−1)	67.2 ± 7.0	37.8 ± 2.9	48.8 ± 3.3	41.1 ± 3.5	42.4 ± 4.2	93.8 ± 18.7**
ENa‡	(μmol/min)	0.05±0.02	0.06±0.01	0.26±0.07	0.07±0.03*	0.35±0.03	0.19±0.04**
EK§	(μmol/min)	0.3 ± 0.06	0.24 ± 0.04	0.28 ± 0.03	0.44 ± 0.03*	0.17 ± 0.03	0.20 ± 0.07
PNa||	(mmol/l)	152.6 ± 3.5	149.0 ± 0.4	146.0 ± 0.6	147.0 ± 0.9	149.1 ± 1.2	149.8 ± 0.9
Pk¶	(mmol/l)	4.41 ± 0.34	4.02 ± 0.19	4.25 ± 0.08	4.55 ± 0.14	4.83 ± 0.34	3.72 ± 0.11**
PCort#	(nmol/l)	515 ± 78	425 ± 21	294 ± 24	330 ± 34	429 ± 44	698 ± 48**
Paldo**	(pmol/l)	1615 ±81	809 ± 103**	537 ± 164	421 ± 94	332±59	39±0.6a

^*Filtration fraction,

^†renal vascular resistance,

^‡urinary excretion of sodium and

^§potassium and plasma concentrations of

^||sodium,

^¶potassium,

^#corticosterone and

^**aldosterone.