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. 1976 Jan;3(1):205–218. doi: 10.1093/nar/3.1.205

Protonated polynucleotide structures. 18. Interaction of oligocytidylates with poly (G).

B L Haas, W Guschlbauer
PMCID: PMC342888  PMID: 1250698

Abstract

The faculty for and degree of oligo(C)-poly(G) interaction is described as an essentially chain length - sensitive phenomenon. At neutral pH under suitable experimental conditions, oligocytidylates of chain length greater than four associate with poly(G) to form double-stranded structures, as does poly(C). The extent of complex formation increases with degree of polymerization. The complex at acid pH is shown to be triple-stranded, of stoicheometry 2C/1G. The observation of a 2G/1C artifact is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnott S., Chandrasekaran R., Marttila C. M. Structures for polyinosinic acid and polyguanylic acid. Biochem J. 1974 Aug;141(2):537–543. doi: 10.1042/bj1410537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chantot J. F., Haertle T., Guschlbauer W. Nucleoside conformations. XIII. Circular dichroïsm of guanosine gels and the conformation of GpG and poly (G). Biochimie. 1974;56(4):501–507. doi: 10.1016/s0300-9084(74)80065-9. [DOI] [PubMed] [Google Scholar]
  3. LIPSETT M. N. COMPLEX FORMATION BETWEEN POLYCYTIDYLIC ACID AND GUANINE OLIGONUCLEOTIDES. J Biol Chem. 1964 Apr;239:1256–1260. [PubMed] [Google Scholar]
  4. Michelson A. M., Massoulié J., Guschlbauer W. Synthetic polynucleotides. Prog Nucleic Acid Res Mol Biol. 1967;6:83–141. doi: 10.1016/s0079-6603(08)60525-5. [DOI] [PubMed] [Google Scholar]
  5. Michelson A. M., Monny C. Polynucleotides. X. Oligonucleotides and their association with polynucleotides. Biochim Biophys Acta. 1967 Nov 21;149(1):107–126. doi: 10.1016/0005-2787(67)90695-8. [DOI] [PubMed] [Google Scholar]
  6. Pochon F., Michelson A. M. Polynucleotides. VI. Interaction between polyguanylic acid and polycytidylic acid. Proc Natl Acad Sci U S A. 1965 Jun;53(6):1425–1430. doi: 10.1073/pnas.53.6.1425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sarocchi M. T., Courtois Y., Guschlbauer W. Protonated polynucleotide structures. Specific complex formation between polycytidylic acid and guanosine or guanylic acids. Eur J Biochem. 1970 Jul;14(3):411–421. doi: 10.1111/j.1432-1033.1970.tb00305.x. [DOI] [PubMed] [Google Scholar]
  8. Thiele D., Guschlbauer W. Polynucléotides protonés. VII. Transitions thermiques entre differents complexes de l'acide polyinosinique et de l'acide polycytidylique en milieu acide. Biopolymers. 1969;8(3):361–378. doi: 10.1002/bip.1969.360080307. [DOI] [PubMed] [Google Scholar]
  9. Thiele D., Guschlbauer W. Protonated polynucleotide structures. IX. Disproportionation of poly (G)-poly (C) in acid medium. Biopolymers. 1971;10(1):143–157. doi: 10.1002/bip.360100111. [DOI] [PubMed] [Google Scholar]
  10. Zmudzka B., Bollum F. J., Shugar D. Poly-5-methyldeoxycyctidylic acid and some alkylamino analogs. Biochemistry. 1969 Jul;8(7):3049–3059. doi: 10.1021/bi00835a054. [DOI] [PubMed] [Google Scholar]

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