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. 1976 Jan;3(1):231–235. doi: 10.1093/nar/3.1.231

A new synthesis of inosine from 5-amino-1-beta-D-ribofuranosyl-4-imidazole-carboxamide.

M Okutsu, A Yamazaki
PMCID: PMC342890  PMID: 1250700

Abstract

Inosine was prepared (15% yield) by treatment of 5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide (AICA-riboside) with chloroform in the presence of sodium methoxide. This ring closure can be reasonably explained by assuming the formation of dichlorocarbene from chloroform and alkali. Carbon tetrachloride or hexachloroethane as a carbene source was more effective for the ring closure of AICA-riboside, giving inosine in 48% and 51% yields respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GREENBERG G. R., SPILMAN E. L. Isolation of 5-amino-4-imidazolecarboxamide riboside. J Biol Chem. 1956 Mar;219(1):411–422. [PubMed] [Google Scholar]

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