Table 4.

Prognostic significance of presence of RD in patients in morphologic CR by univariate Cox analyses

	OS from end of induction 1		RFS from end of induction 1
	HR (95% CI)	P	HR 95% CI	P
Univariate Cox analyses
RD at end of induction 1
Negative	1		1
Positive	2.46 (1.35-4.47)	.003	2.46 (1.52-3.97)	< .001
Molecular risk group
Standard	1		1
Favorable (CBF, NPM1, CEBPA)	0.52 (0.25-1.09)	.083	0.83 (0.49-1.40)	.484
Unfavorable (−7, −5/del(5q), FLT3-ITD high AR)	3.36 (1.50-7.55)	.003	2.72 (1.30-5.68)	.008
WBC count at study entry
< 100 000/μL	1		1
≥ 100 000/μL	0.56 (0.22-1.41)	.215	0.79 (0.42-1.50)	.470
Multivariate cox analyses
RD at end of induction I
Negative	1		1
Positive	1.87 (0.97-3.58)	.060	2.38 (1.43-3.97)	< .001
Molecular risk group
Standard	1		1
Favorable (CBF, NPM1, CEBPA)	0.59 (0.28-1.25)	.167	0.75 (0.55-1.62)	.841
Unfavorable (−7, −5/del(5q), FLT3-ITD high AR)	3.20 (1.42-7.21)	.005	2.84 (1.35-5.97)	.006
WBC count at study entry
< 100 000/μL	1		1
≥ 100 000/μL	0.71 (0.28-1.82)	.476	0.93 (0.49-1.79)	.837

RD indicates residual disease; CR, complete remission; OS, overall survival; RFS, relapse-free survival; HR, hazards ratio; CI, confidence interval; ITD, internal tandem duplication; AR, absolute risk; and WBC, white blood cell.