Table 2.

CLL risk allele genotyping

SNP	Locus	Gene	Risk allele	White CLL RAF*	African American CLL RAF (Duke)	African American CLL RAF (CRC)	African American CLL RAF (Duke/CRC)	P†	P‡	African American control RAF (GWA + HapMap)§	P‖
rs17483466	2q13	ACOXL	G	0.26	0.11	0.07	0.09	< .001	.54	0.06	.18
rs13397985	2q37.1	SP140	G	0.25	0.17	0.13	0.15	.002	.61	0.10	.06
rs757978	2q37.3	FARP2	A	0.13	0.10	0.10	0.10	.22	1	0.08	.46
rs872071	6p25.3	IRF4	G	0.56	0.15	0.12	0.13	< .001	.56	0.09	.13
rs1050976	6p25.3	IRF4	T	0.48	0.15	0.12	0.13	< .001	.56	0.18	.27
rs1050979	6p25.3	IRF4	G	0.47	0.15	0.12	0.13	< .001	.56	—	—
rs2456449	8q24.21	—	G	0.41	0.22	0.21	0.21	< .001	.95	0.18	.27
rs735665	11q24.1	SF3A3P2	A	0.27	0.10	0.07	0.08	< .001	1	0.05	.09
rs7169431	15q21.3	—	A	0.11	0.24	0.21	0.22	< .001	.69	0.23	.82
rs4777184	15q23	—	T	0.47	0.32	0.29	0.31	< .001	.78	0.29	.69
rs783540	15q25.2	CPEB1	G	0.42	0.31	0.47	0.41	.93	.03	0.43	.67
rs305061	16q24.1	IRF8	T	0.70	0.82	0.90	0.87	< .001	.11	0.85	.34
rs391525	16q24.1	IRF8	A	0.75	0.63	0.67	0.66	.004	.67	0.61	.23
rs1036935	18q21.1	—	T	0.26	0.33	0.40	0.38	< .001	.36	0.32	.10
rs11083846	19q13.32	PRKD2	A	0.27	0.08	0.13	0.11	< .001	.46	0.07	.09

— indicates not applicable.

^*White risk allele frequencies (RAF) were abstracted and compiled from previously published reports; reported allele frequencies are for the disease risk-associated allele (supplemental Table 1).

^†Comparison of RAF from pooled Duke and CRC African American CLL cohorts with published white CLL RAF.

^‡Comparison of Duke African American CLL with CRC African American CLL.

^§African American control RAF were pooled from HapMap data (n = 56-57) and genotypes from African American controls participating in a prostate cancer genome-wide SNP association study (n = 474).^20,21

^‖Comparison of RAF from pooled Duke and CRC African American CLL cohorts with pooled African American control CLL RAF.