Figure 7. (A) Levels of glucose (mg/dl) measured over 180 min after an oral glucose load in male ZDF rats (n = 4) prior to transplantation of E28 pig pancreatic primordia (diabetic) or following transplantation (Transplant); (B) levels of porcine insulin (ng/ml) measured over 120 min after an oral glucose load in transplanted ZDF rats (n = 4). (C) Levels of glucose (mg/dl) measured over 120 min after i.v. insulin was administered to ZDF rats (n = 4); (D) levels of porcine insulin (ng/ml/g tissue wet weight) measured over 60 min in a solution containing mesenteric lymph node tissue from diabetic ZDF rats into which pig pancreatic primordia had been transplanted previously (n = 4). Immediately after measurements were made at time 0, glucose was added so as to increase the concentration from 3 mM to 20 mM, a range over which insulin secretion is stimulated in vivo. Data are expressed as mean ± SE. Reproduced with permission.¹⁴