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. 2012 Jul 1;8(7):1098–1112. doi: 10.4161/auto.20268

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graphic file with name auto-8-1098-g7.jpg — Figure 7. Involvement of autophagy in SN38 resistance depends upon MAPK14. (A) Western blot analysis of LC3-I and II and MAPK14 expression in HCT116-TP53KO-ShLuc and HCT116-TP53KO-ShMAPK14 cells after treatment or not (NT) with 2 nM SN38 alone (SN) or with 10 nM 3-methyladenine (SN+3MA) for 96 h. (B) Western blot analysis of LC3-I and II of HCT116-TP53KO-ShLuc, HCT116-TP53KO-ShMAPK11, HCT116-TP53KO-ShMAPK12 and HCT116-TP53KO-ShMAPK13 cells after treatment or not (NT) with 2 nM SN38 alone (SN) for 96 h. (C) SRB assays to assess the cytotoxicity of SN38 alone or in combination with 3-methyladenine (SN38+3MA) in HCT116-TP53KO-ShLuc and HCT116-TP53KO-ShMAPK14 cells. (D) SRB assays to assess SN38 cytotoxicity of HCT116-TP53KO-ShLuc and HCT116-TP53KO-ShMAPK14 cells transfected with control siRNA or anti-ATG5 or -ATG7 siRNAs.