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. 1976 May;3(5):1139–1149. doi: 10.1093/nar/3.5.1139

The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.

A R Morgan, R L Cone, T M Elgert
PMCID: PMC342976  PMID: 181730

Abstract

Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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