Table 2. Classification of class 3 illegitimate diploid chromosome rearrangements.
| Classa | Strain | Essential gene depleted | Type of chromosome rearrangement | Chromosomes involved | Size of altered chromosome (kb) | Boundaries of chromosome rearrangements |
|---|---|---|---|---|---|---|
| 3A(i)b | MCM7-2-57-1 | MCM7 | Translocation | III/VII | 690 | FS2; |
| YGRCTy1-2, YGRCTy2-1 | ||||||
| 3A(i) | RFC2-1-1-1 | RFC2 | Translocation | III/VII | 710 | FS1; YGRWTy1-1 |
| 3A(i) | RFC2-1-1-2 | RFC2 | Translocation | III/VII | 710 | FS1; YGRWTy1-1 |
| 3A(i)b | SPT16-1-3-2 | SPT16 | Translocation | III/XV | 640 | FS1; YORWTy1-2 |
| 3A(ii)b | CDC45-4-4-1 | CDC45 | Ectopic BIR | III/III | 120 | YCLWTy2-1; |
| YCRCδ6 | ||||||
| 3A(ii) | CDC45-4-52-1 | CDC45 | Ectopic BIR | III/III | 140 | YCLWTy2-1; |
| YCRCδ7 | ||||||
| 3A(ii)b | MCM7-6-1-1 | MCM7 | Ectopic BIR | III/III | 140 | YCLWTy2-1; |
| YCRCδ7 | ||||||
| 3A(ii) | RFC2-2-56-1 | RFC2 | Ectopic BIR | III/III | 140 | YCLWTy2-1; |
| YCRCδ7 | ||||||
| 3A(ii) | RFC2-2-6-1 | RFC2 | Ectopic BIR | III/III | 120 | YCLWTy2-1; |
| YCRCδ6 | ||||||
| 3A(ii) | RFC2-2-6-2 | RFC2 | Ectopic BIR | III/III | 120 | YCLWTy2-1; |
| YCRCδ6 | ||||||
| 3A(ii) | SPT16-1-55-1 | SPT16 | Ectopic BIR | III/III | 120 | YCLWTy2-1; |
| YCRCδ6 | ||||||
| 3A(ii)b | SPT16-2-1-1 | SPT16 | Ectopic BIR and interstitial deletion | III/III and V | 170 (chrIII) 520 (chrV) | YCLWTy2-1; FS2 (chrIII) and YERCTy1-1; YERCTy1-2 (chrV) |
| 3Bb | DPB11-1-1-2 | DPB11 | Arm deletion | III | 150 | FS1 |
| 3B | MCM7-4-1-2 | MCM7 | Arm deletion | III | 170 | FS2 |
| 3B | SPT16-2-51-1 | SPT16 | Arm deletion | III | 120 | YCRCδ6 |
| 3B | SPT16-2-51-2 | SPT16 | Arm deletion | III | 120 | YCRCδ6 |
| 3Db | RFC2-1-52-1 | RFC2 | Hawthorne deletion | III | 220 | MATα, HMR |
| 3Fb | DPB11-2-56-1 | DPB11 | Chromosome fusion | III/XVI | 970 | YCLWTy2-1; |
| YPLWTy1-1 | ||||||
| 3Fb | NSE1-4-5-1 | NSE1 | Chromosome fusion | III/V | 530 | YCLWTy2-1; YERCTy1-1 |
| 3F | NSE1-6-51-1 | NSE1 | Chromosome fusion | III/V | 580 | YCLWTy2-1; YERCTy1-2 |
| 3Fb | UBC9-1-51-1 | UBC9 | Chromosome fusion | III/XVI | 930 | YCLWTy2-1; YPRWTy1-3, YPRCTy1-4 |
| 3F | UBC9-1-51-2 | UBC9 | Chromosome fusion | III/XVI | 930 | YCLWTy2-1; YPRWTy1-3, YPRCTy1-4 |
| 3F | UBC9-1-51-3 | UBC9 | Chromosome fusion | III/XVI | 930 | YCLWTy2-1; YPRWTy1-3, YPRCTy1-4 |
a
All strains were examined by comparative genome hybridization on a microarray.
b
Genome rearrangements predicted from microarray analysis were confirmed by Southern blot analysis.