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. 1977 Dec;4(12):4313–4322. doi: 10.1093/nar/4.12.4313

Genetically determined differences in concentrations of isoaccepting tRNAs in Escherichia coli.

J Thomale, G Nass
PMCID: PMC343243  PMID: 341085

Abstract

Two examples of genetically determined altered concentrations of isoaccepting tRNAs are presented. The concentrations of isoaccepting tRNAsThr are selectively changed by a mutation causing a fourfold overproduction of the cognate aminoacyl-tRNA-synthetase, the threonyl-tRNA synthetase, whereas the distribution of isoaccepting tRNAs of four control tRNA-species in these E. coli mutants was not affected by that mutation. Secondly evidence is presented for a correlation between mutations in structural genes of aminoacid biosynthetic enzymes and alterations in concentrations of cognate isoaccepting tRNAs in two different E. coli strains, auxotrophic for threonine, isoleucine/valine and leucine, and arginine respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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