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. 1977 Dec;4(12):4357–4370. doi: 10.1093/nar/4.12.4357

RNA methylation and control of eukaryotic RNA biosynthesis: processing and utilization of undermethylated tRNAs in CHO cells.

F Amalric, J P Bachellerie, M Caboche
PMCID: PMC343246  PMID: 600798

Abstract

The role of RNA methylations in the control of tRNA production and utilization for protein biosynthesis has been investigated through a study of the effects in vivo of cycloleucine a specific and potent inhibitor of S adenosyl-methionine mediated methylation. During the cycloleucine treatment, the rate of appearance of newly synthetized tRNAs into the cytoplasm is markedly reduced (about 50%). These molecules are extensively (more than 90%) undermethylated and are integrated into polysomes, but at a slower rate than normally methylated tRNAs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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