Table 2.
Cross-sectional Correlates of Adipo-IR at Baseline and at 96 weeks
| Correlates at baseline or 96 weeks | Baseline Adipo-IR | Adipo-IR at 96 weeks | ||
|---|---|---|---|---|
| Estimated ratio of Adipo-IR (95% CI) |
P* | Estimated ratio of Adipo-IR (95% CI) |
P‡ | |
| Demographics | ||||
| Female vs. Male | 1.13 (0.79, 1.61) | 0.50 | 2.06 (1.40, 3.03) | <0.001 |
| Hispanic vs. other ethnicities | 1.16 (0.89, 1.50) | 0.27 | 1.09 (0.80, 1.50) | 0.56 |
| Age at Randomization | 1.00 (0.99, 1.01) | 0.68 | 0.999 (0.988, 1.010) | 0.89 |
| Anthropometrics | ||||
| BMI (kg/m2) | 1.06 (1.02, 1.09) | 0.001 | 1.05 (1.01, 1.08) | 0.004 |
| Waist circumference (cm) | 0.99 (0.98, 1.00) | 0.12 | 1.01 (1.00, 1.02) | 0.05 |
| Total body fat (%) | 1.02 (0.99, 1.04) | 0.16 | 0.98 (0.96, 1.00) | 0.12 |
| Laboratory measures | ||||
| AST (U/L) | 0.998 (0.993, 1.003) | 0.46 | 1.00 (0.99, 1.01) | 0.92 |
| ALT (U/L) | 1.001 (0.998, 1.004) | 0.39 | 1.004 (0.999, 1.008) | 0.08 |
| Glucose (mg/dl) | 1.01 (1.00, 1.02) | 0.001 | 1.01 (1.00, 1.02) | 0.001 |
| Triglycerides (mg/dl) | 1.00 (1.00, 1.00) | 0.62 | 1.00 (1.00, 1.00) | 0.96 |
| Total cholesterol (mg/dl) | 1.002 (0.999, 1.005) | 0.17 | 1.004 (1.001, 1.008) | 0.03 |
| HDL cholesterol (mg/dl) | 0.997 (0.988, 1.006) | 0.46 | 0.995 (0.981, 1.004) | 0.29 |
| Histology | ||||
| Fibrosis score: 3–4 vs. <3 | 1.33 (1.05, 1.69) | 0.02 | 1.03 (0.74, 1.41) | 0.88 |
| Steatosis Grade 2–3 vs. 0–1 | 1.21 (0.96, 1.51) | 0.10 | 0.99 (0.75, 1.31) | 0.93 |
| Lobular inflammation >2 foci vs. 0–2 foci | 1.02 (0.80, 1.28) | 0.89 | 1.08 (0.78, 1.50) | 0.63 |
| Ballooning: Many vs. None/Few | 1.16 (0.93, 1.45) | 0.20 | 0.99 (0.72, 1.37) | 0.97 |
| NAS>=5 vs. <5 | 0.91 (0.68, 1.21) | 0.52 | 1.00 (0.66, 1.52) | 1.00 |
| Resolution of NASH | - | - | 0.74 (0.56, 0.98) | 0.03 |
*
P values were from multiple linear regression model, regressing the logarithm of Adipo-IR at baseline on the listed correlates at baseline.
‡
P values were from multiple linear regression model, regressing the logarithm of Adipo-IR at 96 weeks on the listed correlates at 96 weeks.
Abbreviations: BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDL, low-density lipoprotein; Adipo-IR, adipose tissue insulin resistance; NAS, NAFLD activity score; NASH, nonalcoholic steatohepatitis.