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. 1974 Jan;1(1):53–61. doi: 10.1093/nar/1.1.53

Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid

Morio Ikehara 1, Toshikazu Fukui 1, Toshiko Koide 1, Junko Inaba 1
PMCID: PMC343323  PMID: 10793659

Abstract

Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has similar physical properties to poly(I), but has a low thermal stability in the double-stranded complex with poly(C). Poly(7-deaza I), in contrast, forms a more stable triple-stranded complex with poly(A) than 2 poly(I). poly(A), presumably due to the higher pK value.

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Selected References

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  1. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. Inducers of interferon and host resistance, V. In vitro studies. Proc Natl Acad Sci U S A. 1968 Sep;61(1):340–346. doi: 10.1073/pnas.61.1.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hagenberg L., Gassen H. G., Matthaei H. Synthesis and coding properties of poly(c 1 A), poly(c 3 A), poly(c 7 A) and poly(h 6 A). Biochem Biophys Res Commun. 1973 Feb 20;50(4):1104–1112. doi: 10.1016/0006-291x(73)91520-9. [DOI] [PubMed] [Google Scholar]
  3. Ikehara M., Fukui T. Some physical properties of poly 7-deazaadenylic acid (poly Tubercidin phosphoric acid). J Mol Biol. 1968 Dec;38(3):437–441. doi: 10.1016/0022-2836(68)90399-9. [DOI] [PubMed] [Google Scholar]
  4. Ikehara M., Hattori M. Polynucleotides. XI. Synthesis and properties of poly(2-methylinosinic acid). Biochim Biophys Acta. 1972 Jun 22;272(1):27–32. [PubMed] [Google Scholar]
  5. Ikehara M., Hattori M. Polynucleotides. XV. Synthesis and properties of polynucleotides containing N 2 -dimethylguanylic acid residues in polyinosinate and polyadenylate chains. Biochim Biophys Acta. 1972 Nov 16;287(1):9–15. doi: 10.1016/0005-2787(72)90325-5. [DOI] [PubMed] [Google Scholar]
  6. Ikehara M., Hattori M. Synthesis and properties of poly(2-methylthioinosinic acid). Biochim Biophys Acta. 1972 Apr 26;269(1):27–36. doi: 10.1016/0005-2787(72)90070-6. [DOI] [PubMed] [Google Scholar]
  7. Ikehara M., Hattori M. Synthesis and properties of polyribonucleotides containing N 2 -methyl and N 2 -dimethylguanylic acid in polyguanylic acid. Biochemistry. 1971 Sep 14;10(19):3585–3590. doi: 10.1021/bi00795a016. [DOI] [PubMed] [Google Scholar]
  8. SIGLER P. B., DAVIES D. R., MILES H. T. A displacement reaction between a polynucleotide Helix and a random coil. J Mol Biol. 1962 Dec;5:709–717. doi: 10.1016/s0022-2836(62)80097-7. [DOI] [PubMed] [Google Scholar]
  9. WILLIAMS F. R., GRUNBERG-MANAGO M. POLYNUCL'EOTIDE PHOSPHORYLASE HAUTEMENT PURIFI'EE 'A PARTIR DE E. COLI. Biochim Biophys Acta. 1964 Jul 8;89:66–89. [PubMed] [Google Scholar]

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