Abstract
A method for the rapid preparation of the thymineanalogue, 5-vinyluracil, in 83% yield from 5-(1-hydroxyethyl)uracil via the methanesulphonyl ester is reported.
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Selected References
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- Chelton E. T., Evans C. H., Jones A. S., Walker R. T. Incorporation of 5-substituted uracil derivatives into nucleic acids. II. Incorporation of 5-vinyluracil into the DNA of Escherichia coli. Biochim Biophys Acta. 1973 Jun 8;312(1):38–44. doi: 10.1016/0005-2787(73)90050-6. [DOI] [PubMed] [Google Scholar]
- Fissekis J. D., Sweet F. The chemistry of some 5-(2-hydroxyalkyl)uracil derivatives and a synthesis of 5-vinyluracil. J Org Chem. 1973 Jan 26;38(2):264–269. doi: 10.1021/jo00942a015. [DOI] [PubMed] [Google Scholar]
- Fissekis J. D., Sweet F. The chemistry of the base-catalyzed condensation of some 3-alkoxy-and 3-alkoxy-2-dialkoxymethyl esters with ureas. Synthesis of 5-substituted uracils. J Org Chem. 1973 Jun 1;38(71):1963–1970. doi: 10.1021/jo00951a001. [DOI] [PubMed] [Google Scholar]