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. 1974 Aug;1(8):1017–1030. doi: 10.1093/nar/1.8.1017

CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues

Ch Zimmer 1, E Birch-Hirschfeld 1, R Weiss 1
PMCID: PMC343408  PMID: 10793732

Abstract

CD studies of the deoxyoligomer series d(pT)n and d(pA)n show increasing CD maxima for oligo (dT)'s with chain length variation from two to seven, while oligo (dA)'s exhibit a decreasing CD maximum. Concentrated solutions of NaClO4 cause a decrease in the CD of longer oligo (dT)'s towards the CD of d(pT)2 which is different from oligo dA's. Probably base-sugar interactions are important in the observed conformational effects. The chemically synthesized oligomers dpApApTpT and dpTpApTpA show deviations in their CD spectra which reflect a dominating conformational effect of d(pA)2 in the former but not in the alternating isomer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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