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. 1974 Dec;1(12):1691–1701. doi: 10.1093/nar/1.12.1691

Synthesis and properties of some cyclic AMP alkyl phosphotriesters

RN Gohil 1, RG Gillen 1, J Nagyvary 1
PMCID: PMC343448  PMID: 4375277

Abstract

Cyclic AMP was converted to its phosphotriesters according to the classical approach of phosphate activation with a sulfonyl chloride, followed by esterification with an alcohol. The methyl, ethyl, propyl, butyl and cetyl triesters were prepared, and some of their physical-chemical properties determined. Alkaline hydrolysis of these alkyl phosphotriesters resulted predominantly in ring opening. On the other hand, nucleophilic attack by thiourea led to the formation of cAMP as the main product. The conclusion can be drawn from these results that cAMP phosphotriesters could serve as suitable storage forms of cAMP, and cyclic triesters may be the best vehicle of transporting nucleotides through biological membranes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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