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. 1975 Nov;2(11):2101–2109. doi: 10.1093/nar/2.11.2101

Alterations of DNA-dependent DNA polymerase activities in the immature quail oviduct in response to estrogen stimulation.

H J Rohde, W E Müller, R K Zahn
PMCID: PMC343576  PMID: 1052532

Abstract

Administration of diethylstilbestrol, an estrogen analogue, to immature female quails causes an increase of extractable DNA-dependent DNA polymerase activities from the oviduct. At least two forms of polymerases have been determined, a high molecular weight polymerase (210,000 daltons) and a low molecular weight polymerase (34,000 daltons) calculated from column chromatography Sephadex G-200. During the primary hormone stimulation the amount of extractable enzyme reaches a maximum on the fifth day after daily injections of the hormone. In the period of withdrawal the activities decrease and reach values similar to those determined in the unstimulated oviducts. During secondary stimulation the polymerase activities increase again the first day; subsequently the values decrease drastically. The alterations in enzyme activity correlate with the DNA synthesis in the oviduct, as measured by analytical determination of the DNA content.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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