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. 1975 Dec;2(12):2305–2313. doi: 10.1093/nar/2.12.2305

Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).

E De Clercq, A Billiau, M Hattori, M Ikehara
PMCID: PMC343598  PMID: 79996

Abstract

Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine (Moloney) sarcoma virus, while under the same conditions the unsubstituted parent compound poly(I) showed little, if any, inhibitory effect. Copolymers of inosinic acid (I) and 2-methylthioinosinic acid2(ms2I) showed an intermediary effect, depending on the I:ms2I ratio. Poly(ms2I) also inhibited the transformation of normal cells by murine (Moloney) sarcoma virus, as assessed by an infectious center assay.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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