Skip to main content
PMC home page
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1977 May;4(5):1257–1265. doi: 10.1093/nar/4.5.1257

Estimation of DNA sequence divergence from comparison of restriction endonuclease digests.

W B Upholt
PMCID: PMC343753  PMID: 896461

Abstract

An estimation of the DNA sequence divergence between defined DNA secquences of individuals or species may be made from comparison by gel electrophoresis of restriction endonuclease digests. This analysis is applicable to purified DNA sequence of moderate complexity (1-100 X 10(6) daltons) which have diverged by base substitution of 0.5 to 25% of nucleotides.

Full text

PDF
1257

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fitch W. M. The molecular evolution of cytochrome c in eukaryotes. J Mol Evol. 1976 Jun 23;8(1):13–40. doi: 10.1007/BF01738880. [DOI] [PubMed] [Google Scholar]
  2. King M. C., Wilson A. C. Evolution at two levels in humans and chimpanzees. Science. 1975 Apr 11;188(4184):107–116. doi: 10.1126/science.1090005. [DOI] [PubMed] [Google Scholar]
  3. Laird C. D., McConaughy B. L., McCarthy B. J. Rate of fixation of nucleotide substitutions in evolution. Nature. 1969 Oct 11;224(5215):149–154. doi: 10.1038/224149a0. [DOI] [PubMed] [Google Scholar]
  4. McCarthy B. J., Farquhar M. N. The rate of change of DNA in evolution. Brookhaven Symp Biol. 1972;23:1–43. [PubMed] [Google Scholar]
  5. Nathans D., Smith H. O. Restriction endonucleases in the analysis and restructuring of dna molecules. Annu Rev Biochem. 1975;44:273–293. doi: 10.1146/annurev.bi.44.070175.001421. [DOI] [PubMed] [Google Scholar]
  6. Prager E. M., Wilson A. C. The dependence of immunological cross-reactivity upon sequence resemblance among lysozymes. II. Comparison of precipitin and micro-complement fixation results. J Biol Chem. 1971 Nov 25;246(22):7010–7017. [PubMed] [Google Scholar]
  7. Salser W., Bowen S., Browne D., el-Adli F., Fedoroff N., Fry K., Heindell H., Paddock G., Poon R., Wallace B. Investigation of the organization of mammalian chromosomes at the DNA sequence level. Fed Proc. 1976 Jan;35(1):23–35. [PubMed] [Google Scholar]
  8. Salser W., Isaacson J. S. Mutation rates in globin genes: the genetic load and Haldane's dilemma. Prog Nucleic Acid Res Mol Biol. 1976;19:205–220. doi: 10.1016/s0079-6603(08)60919-8. [DOI] [PubMed] [Google Scholar]
  9. de Haën C., Neurath H., Teller D. C. The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships. J Mol Biol. 1975 Feb 25;92(2):225–259. doi: 10.1016/0022-2836(75)90225-9. [DOI] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES