Skip to main content
. Author manuscript; available in PMC: 2012 Sep 11.
Published in final edited form as: Nature. 2011 Jul 13;475(7355):183–188. doi: 10.1038/nature10232

Figure 5. Ten-step enantioselective synthesis of (−)-akuammicine.

Figure 5

Reagents and conditions are as follows. a, TFA, PhSH, 60 °C. b, (Z)-1-bromo-2-iodobut-2-ene (18), K2CO3, DMF, RT. c, 20 mol% Pd(OAc)2, NaHCO3, Bu4NCl, MeCN, 65 °C.