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. 1974 Mar;1(3):373–385. doi: 10.1093/nar/1.3.373

Control of transcription of the reovirus genome

M Nonoyama 1,2, S Millward 1,2, AF Graham 1,2
PMCID: PMC344022  PMID: 10793672

Abstract

The ten double-stranded RNA segments of the reovirus genome are not transcribed at equal frequencies until later times during the course of infection. When an inhibitor of protein synthesis such as cycloheximide was added to infected cells at the beginning of infection, only four of the ten segments were transcribed. By two hr post infection, five and possibly seven of the segments were being transcribed. By four hr post infection all ten segments were being transcribed but not yet at equal relative frequencies. The transcription pattern at intermediate (4 hr) and late (10 hr) times were verified without using cycloheximide. A repressor present in the host cell may be responsible for controlling transcription of the reovirus genome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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