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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Metabolism. 2012 May 17;62(1):12–20. doi: 10.1016/j.metabol.2012.04.009

Figure 1. MicroRNA processing pathways in the nucleus and cytoplasm.

Figure 1

Dotted lines: segments of RNA that are cleaved from precursor molecules during processing of mature microRNA

Solid lines: segments of RNA that are retained during processing and incorporated in mature microRNA

RISC: ribonucleoprotein miR induced silencing complex

DGCR8 protein: DiGeorge syndrome critical region gene 8, whish is an essential cofactor protein for primary miR processing