Table 1. Inactive lever responding during self-administration, extinction, and reinstatement.
The inactive lever presses for the average of the last 3 sessions of self-administration, sessions 1 and 7 of extinction, and cue- and cocaine-induced reinstatement are shown as the mean±SEM for each group.
| Group | Self-administration | Extinction | Reinstatement | ||
|---|---|---|---|---|---|
| Last 3 sessions | Session 1 | Session 7 | Cue | Cocaine | |
| Veh/Veh | 0.2 ± 0.1 | 27.0 ± 3.4 | 8.3 ± 1.9 | 9.7 ± 2.7 | 6.8 ± 1.1 |
| Veh/SB | 18.8 ± 5.5 | 9.5 ± 4.0 | 20.0 ± 5.6 | 5.0 ± 1.1 | |
| SB/Veh | 0.9 ± 0.4 | 17.1 ± 5.4 | 6.3 ± 1.5 | 7.7 ± 1.1 | 3.1 ± 1.1 |
| SB/SB | 19.1 ± 2.7 | 7.6 ± 2.3 | 10.0 ± 2.7 | 4.0 ± 0.8 | |
| Veh-Veh | 0.1 ± 0.02 | 21.9 ± 1.8 | 6.1 ± 1.0 | 6.1 ± 1.1 | 6.3 ± 2.0 |
| Veh-SB | 7.8 ± 1.6 | 3.9 ± 1.9 | |||
| SB-Veh | 12.6 ± 3.5 | 3.8 ± 0.8 | 6.4 ± 2.5 | 6.4 ± 3.7 | |
| SB-SB | 4.1 ± 1.1 | 2.8 ± 1.2 | |||
| SB (post)-Veh | 19.6 ± 4.5 | 6.6 ± 1.7 | 6.9 ± 2.7 | 5.6 ± 2.0 | |
| SB (post)-SB | 2.1 ± 1.4 | 3.7 ± 1.7 | |||