Figure 5.

Experience-dependent changes in NAcc spine density in SR−/− and WT mice. (a) The analysis of nucleus accumbens core (NAcc) spine density in Golgi-fixed sections of SR−/− and WT littermate mice following repeated saline exposure (control), repeated AMPH exposure (sensitized), or following extinction of conditioned hyperactivity in AMPH-exposed (extinguished) subjects. ^#Significant difference as compared with the control condition of the same genotype (p<0.01, Bonferroni). ^*Significant difference between genotypes of the same condition (p<0.05, Bonferroni). Results are presented as means±SEM. (b) Examples of Golgi-stained terminal dendrites for each condition and genotype are shown.