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. 1974 Sep;1(9):1183–1199. doi: 10.1093/nar/1.9.1183

Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes

Guido C F Pedrali Noy 1, Leda Dalpra 1, Antonia M Pedrini 1, Giovanni Ciarrocchi 1, Elena Giulotto 1, Fiorella Nuzzo 1, Arturo Falaschi 1
PMCID: PMC344339  PMID: 4453522

Abstract

The stimulation of human lymphocytes with phytohaemoagglutinin induces the appearance or increase of several enzymes of DNA metabolism [Pedrini etal., Biochem. Biophys. Res. Comm., 47:1221(1972)]. With long times of stimulation, two phenomena are observed; an increase in the levels of DNA polymerase, of a DNase acting on single-stranded DNA, and of an endonuclease, occurring between the third and fourth day, in parallel with a wave of DNA synthesis;a second wave of increase of the same enzymes and of DNA ligase,occurring between the fifth and eight day when the DNA replication rate, as measured by thymidine-pulses, has decreased to values close to the background.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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