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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 16;64(1):268–282. doi: 10.1016/j.neuropharm.2012.07.013

Figure 5. CX1739 did not alter levels of self-grooming in B6 or BTBR and did not induce hyperactivity or sedation in an open field.

Figure 5

(A) Normally low levels of self-grooming in B6 mice were unchanged after treatment with CX1739. (B) BTBR displayed their innately high levels of repetitive self-grooming after vehicle and CX1739. For the grooming experiments, CX1739 was administered in 25% β-cyclodextrin in water. N = 7-10 per dose for each strain. (C) Total distance traveled in a 30 minute test session in an Accuscan open field was lower after CX1739 (3.0 mg/kg, 10 mg/kg and 30 mg/kg) in B6. *p < 0.05 as compared to peanut butter vehicle. (D) Total distance traveled in a 30 minute test session in an Accuscan open field was not significantly different after CX1739 or peanut butter vehicle treatment in BTBR (D). N=11 per strain per dose. See Supplementary Material S4 for additional open field parameters.