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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Jan;81(1):216–219. doi: 10.1073/pnas.81.1.216

Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?

H Koprowski, D Herlyn, M Lubeck, E DeFreitas, H F Sears
PMCID: PMC344642  PMID: 6582477

Abstract

Inoculation of human subjects with mouse monoclonal antibody results in the production of anti-idiotype antibody that reacts with the binding site of the monoclonal antibody. This reaction is hapten-inhibited, suggesting that an internal image of the antigen is produced by the anti-idiotype response. The anti-idiotype antibody isolated from sera of three patients showed significant crossreactivity. Patients who developed the anti-idiotype antibody improved clinically and had long remission from their disease. The possible presence of the internal image of cancer antigen on the human immunoglobulin molecule may change the conditions under which the immune system reacts to the tumor antigen and may open new approaches to the control of tumor growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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