Correction: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development

Correction

Following publication of our recent article [1], it was brought to our attention that there are errors in Figure 5b and Supplementary Table 2.

The corrected Figure and table are given here as Figure 1 (a corrected version of Figure 5b [1]) and Table 1 (a corrected version of Supplementary Table 2 [1]).

Figure 1.

Adoptive cell transfer of FoxP3- and Bcl-xL-transduced regulatory T cells suppresses collagen-induced arthritis (CIA).

Table 1.

Summary of the mouse arthritis scores of the three experiments

		Score
Days (post immunization)	Mig	Mig-FoxP3	Mig-Bcl-xL-2A-FoxP3
10	0, 0, 0	0, 0, 0	0, 0, 0
20	0, 0, 0	0, 0, 0	0, 0, 0
22	1.00, 0, 0.83	0, 0, 0	0, 0, 0
24	2.00, 0, 1.67	0, 0, 0	0, 0, 0
28	2.67, 1.67, 2.67	0.50, 0, 0.50	0, 0, 0
30	3.30, 2.83, 3.30	0.50, 0, 1.17	0, 0, 0
32	3.67, 3.00, 3.50	0.50, 1.17, 1.50	0, 0, 0
34	3.83, 3.00, 3.67	1.00, 1.67, 1.50	0.83, 0, 0
38	3.83, 3.00, 3.67	1.17, 1.67, 1.83	0.83, 0.50, 0
40	3.83, 3.30, 3.67	1.50, 1.67, 2.00	1.00, 0.50, 0
42	3.83, 3.30, 3.83	1.50, 2.00, 2.17	1.17, 0.50, 0.50
48	3.83, 3.50, 3.83	2.00, 2.00, 2.67	1.50, 0.83, 0.83
50	3.83, 3.50, 3.83	2.00, 2.17, 2.67	1.67, 1.00, 1.00
60	3.83, 3.50, 3.83	2.00, 2.40, 3.00	1.67, 1.00, 1.17

Naive CD4⁺ T cells from DBA/1J mice were stimulated with anti-CD3 plus anti-CD28 antibodies. On days 2 and 3, the cells were transduced with retroviral constructs: vector (Mig), FoxP3 (Mig-FoxP3), or FoxP3 with Bcl-xL (Mig-Bcl-xL-2A-FoxP3). On day 6, green fl uorescent protein-positive (GFP⁺) T cells were sorted and prepared for adoptive cell transfer. CIA was induced in male DBA/1J mice (>4 months old) by one (day 0) intradermal immunization in the base of the tail with 100 μg of bovine type II collagen in complete Freund's adjuvant, containing 5 mg/mL killed Mycobacterium tuberculosis (H37Ra). On day 15 after the immunization, the mice received transduced GFP⁺ cells (2.5 × 10⁶ per mouse, six mice per group). In the following days, the arthritis clinical score was evaluated by examining the paws and using a 4-point scale: 0, normal paw; 1, minimal swelling or redness; 2, redness and swelling involving the entire forepaw; 3, redness and swelling involving the entire limp; 4, joint deformity or ankylosis or both. Values are the mean ± standard error of the mean of data obtained in three experiments, and in each experiment, six mice per group were used.

See related research by Haque et al., http://arthritis-research.com/content/12/2/R66