Figure 4. WIN reduces microglial cell proliferation in the injured cortex 72 hours after neonatal MCAO.
Proliferation of Iba1+ cells is increased in the injured cortex 72 hours after MCAO (A vs B). WIN led to a significant reduction in the number of proliferating Iba1+ cells in the ischemic cortex (C vs B, D). n=6–9 per group; (***) Student’s t-test p<0.001, respectively, vs contralateral MCAO+Veh; (#) Student’s t-test p<0.05 vs core MCAO+Veh.