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Isoflurane (1 mM) effect on glycine-evoked (10 μM) currents in isolated neurons from wild-type and knockin mice. A. Neurons form M287L mice: α1M/M, wild-type; α1M/L, heterozygous; α1L/L, homozygous. B. Neurons form Q266I mice:α1Q/Q, wild-type; α1Q/I, heterozygous; α1I/I, homozygous. Values are means ± S.E.M.; n= 6 for each group; *p <0.05, **p <0.001 versus corresponding wild-type, One-Way ANOVA, Dunnett’s post-hoc test.
