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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Mar;81(5):1389–1390. doi: 10.1073/pnas.81.5.1389

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.

R G Hammonds Jr, P Nicolas, C H Li
PMCID: PMC344839  PMID: 6324189

Abstract

beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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