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. 1984 Feb;81(3):704–707. doi: 10.1073/pnas.81.3.704

The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.

M L Privalsky, R Ralston, J M Bishop
PMCID: PMC344903  PMID: 6322166

Abstract

Avian erythroblastosis virus can transform both fibroblasts and erythroid cells to neoplastic growth. A locus within the virus genome, v-erb B, encodes a membrane glycoprotein essential for the oncogenic properties of the virus. No biochemical function has until now been attributed to the v-erb B protein. We report here that the v-erb B glycoprotein shares strong structural homologies with the tyrosine-specific protein kinases encoded by certain retroviral oncogenes. The patterns of amino acid conservation between the tyrosine-specific protein kinases and the v-erb B protein, and between the v-erb B protein and the catalytic subunit of bovine protein kinase, suggest a possible functional as well as structural relatedness.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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