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. 2002 Nov;40(1-3):31–38. doi: 10.1023/A:1023949620172

Murine Peyer's patch dendritic cells prime naïve CD4+ T cells to produce interferon-γ

Ayuko Sato 1, Masaaki Hashiguchi 1, Satoshi Hachimura 1,✉, Shuichi Kaminogawa 1
PMCID: PMC3449535  PMID: 19003102

Abstract

We investigated the role of Peyer's patch (PP) dendritic cells (DCs) in the production of interferon (IFN)-γ from naïve CD4+ T cells of T cell receptor transgenic mice. PP DCs were found to prime naïve CD4+ T cells for the production of higher levels of IFN-γ, when compared to spleen (SP) DCs. However, a similar level of interleukin-12 (IL-12) production was observed for PP and SP DCs stimulated via the CD40 molecule. In addition, PP DCs expressed slightly higher levels of B7.2 (CD86) compared to SP DCs. This data demonstrates that PP DCs have a distinct function in the induction of IFN-γs and suggests that PP DCs may enhance IFN-γ production via another cytokine or costimulatory molecule, in addition to IL-12.

Keywords: dendritic cells, IFN-γ, IL-12, mucosal immunity, Peyer's patch

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