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. 2003 Nov;43(1-3):155–159. doi: 10.1023/B:CYTO.0000039903.22449.79

Restoration by Prostaglandins E2 and F2α of Resveratrol-Induced Suppression of Hepatoma Cell Invasion in Culture

Daiki Miura 1, Yutaka Miura 1, Kazumi Yagasaki 1
PMCID: PMC3449602  PMID: 19003221

Abstract

In our previous study, resveratrol, a polyphenolic compound in grapes with antioxidative property, and resveratol-loaded rat serum (RS) were found to suppress the invasion of AH109A cells, an ascite hepatoma cell line. The aim of the present study was to investigate whether and which prostaglandins (PGs) would be involved in the invasion of AH109A cells and its suppression by resveratrol and resveratrol-loaded RS, using an in vitro invasion assay system. Not only PGE2 but also PGF2α stimulated the spontaneous invasion of AH109A cells.They also canceled the resveratrol-induced suppression of hepatoma cell invasion. Results obtained suggest an involvement of PGs, especially PGE2, in the invasion of hepatoma cells.

Keywords: hepatoma, invasion, prostaglandin E2, prostaglandin F2α, resveratrol

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