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. 1998 Nov;28(1-3):157–162. doi: 10.1023/A:1008098118491

Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

L K Nielsen 1,✉, J G Bender 2, W M Miller 3, E T Papoutsakis 3
PMCID: PMC3449838  PMID: 19003417

Abstract

In this paper, we develop a simple four parameter population balance model of in vivo neutrophil formation following bone marrow rescue therapy. The model is used to predict the number and type of neutrophil progenitors required to abrogate the period of severe neutropenia that normally follows a bone marrow transplant. The estimated total number of 5 billion neutrophil progenitors is consistent with the value extrapolated from a human trial. The model provides a basis for designing ex vivo expansion protocols.

Keywords: bone marrow rescue therapy, ex vivo expansion, in vivo model, neutropenia

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